Bioavailability: Obtaining data from pharmacokinetic studies in rats, mice and rabbits is the most crucial steps of drug discovery. Determination of the drug exposure of the compound is
In-vivo pharmacokinetic studies are done in rats, mice, rabbits and others like zebrafish systems. First Pass: Clinically, first-pass metabolism is important when the fraction of the dose administered
For these studies, surgical expertise is important i.e. animals are cannulated either by jugular or portal or bile or femoral to infuse or administer compound as well as
In-vivo tissue distribution in rats, mice, rabbits, and other aquatic system like zebra fish provides an in depth analysis of the metabolic fate of the compound within various